What is the maximum time Humira (adalimumab) can be left out of the fridge?

Storage Guidelines for Humira (Adalimumab) Outside the Refrigerator

Humira can be stored at room temperature up to a maximum of 77°F (25°C) for a period of up to 14 days, with protection from light. 1

Standard Storage Requirements

Humira (adalimumab) has specific storage requirements to maintain its efficacy and safety:

• Primary storage: Refrigerate at 36°F to 46°F (2°C to 8°C)
• Room temperature storage: Up to 77°F (25°C) for a maximum of 14 days
• Light protection: Must be stored in original carton until time of administration to protect from light
• DO NOT FREEZE: If frozen, do not use even if thawed 1

Important Considerations When Storing Humira Outside the Refrigerator

When removing Humira from refrigeration:

• Record the date when Humira is first removed from the refrigerator in the spaces provided on the carton and dose tray
• Discard if not used within the 14-day period at room temperature
• Do not store in extreme heat or cold conditions
• Once the 14-day period has elapsed, the medication should be discarded even if not used 1

Research on Extended Storage

Recent research has evaluated the stability of adalimumab biosimilar (SB5) at room temperature for longer periods:

• A 2019 study found that SB5 (adalimumab biosimilar) aged for 36 months remained physicochemically and biologically stable for up to 4 weeks at room temperature (25°C ± 2°C) 2
• However, this extended stability data applies specifically to the biosimilar version and has not been officially approved for the reference product Humira

Common Pitfalls to Avoid

• Exceeding the 14-day limit: Using Humira beyond the 14-day room temperature storage period may compromise its efficacy
• Improper temperature: Exposing Humira to temperatures above 77°F (25°C) may degrade the medication
• Freezing: Never use Humira that has been frozen, even if subsequently thawed
• Light exposure: Failing to protect Humira from light can reduce its potency
• Missing documentation: Not recording the date when removed from refrigeration can lead to uncertainty about the medication's viability

Practical Recommendations for Patients

• When traveling, use insulated containers to maintain appropriate temperature
• Plan ahead for trips longer than 14 days, as you may need to arrange for refrigeration
• Always inspect the medication before use - it should appear clear and colorless
• If uncertain about storage conditions or duration, consult with a healthcare provider rather than using potentially compromised medication

Remember that proper storage is essential to maintain the effectiveness of Humira in treating conditions like rheumatoid arthritis, psoriasis, and Crohn's disease.