Gastroesophageal Reflux Disease (GERD): This condition is characterized by the backflow of stomach acid into the esophagus, leading to symptoms like epigastric pain and bloating, especially after meals. The proximity of symptoms to meal times and the nature of the discomfort make GERD a highly plausible diagnosis.

Functional Dyspepsia: Also known as non-ulcer stomach pain or indigestion, this condition involves recurring signs and symptoms of indigestion that have no obvious cause. Symptoms can include pain or discomfort in the upper abdomen, bloating, and early satiety, which are exacerbated by eating.
Irritable Bowel Syndrome (IBS): While IBS primarily affects the large intestine, it can cause a variety of symptoms including bloating, abdominal pain, and changes in bowel movements. The symptoms can be triggered by eating and may include epigastric discomfort.
Peptic Ulcer Disease: This includes both gastric and duodenal ulcers, which can cause epigastric pain that may be related to eating. The pain can be relieved by eating in duodenal ulcers but worsened in gastric ulcers.

Myocardial Infarction: Although less common, myocardial infarction (heart attack) can present with epigastric discomfort or pain, especially in women, diabetics, and the elderly. It is crucial to consider this diagnosis due to its high mortality rate if missed.
Pancreatitis: Acute pancreatitis can cause severe epigastric pain that radiates to the back, nausea, vomiting, and bloating. It is a medical emergency that requires prompt diagnosis and treatment.
Gastric Cancer: While less likely, gastric cancer can present with epigastric pain, bloating, and weight loss. Early detection is crucial for treatment outcomes.

Gastroparesis: A condition where the stomach takes too long to empty its contents, leading to bloating, nausea, vomiting, and epigastric pain after eating. It can be caused by diabetes, certain medications, or after surgeries.
Eosinophilic Esophagitis or Gastroenteritis: Conditions characterized by an eosinophilic infiltration of the esophagus or stomach, often related to food allergies or atopic diseases, leading to dysphagia, food impaction, and epigastric pain.
Celiac Disease: An autoimmune disorder where the ingestion of gluten leads to damage in the small intestine, causing bloating, abdominal pain, and malabsorption. While it primarily affects the small intestine, it can cause upper gastrointestinal symptoms.