When should I take my next dose of Latuda (Lurasidone) 20mg?

When to Take the Next Dose of Latuda (Lurasidone) 20 mg

Latuda (lurasidone) 20 mg should be taken once daily with food (at least 350 calories), with no need for initial dose titration. 1

Administration Requirements

• Timing: Take once daily at a consistent time
• Food requirement: Must be taken with food containing at least 350 calories
  • Administration with food increases the absorption substantially:
    • Increases AUC approximately 2-fold
    • Increases Cmax approximately 3-fold 1
• Consistency: Maintain the same daily schedule for optimal therapeutic effect

Dosing Considerations

For Adults with Bipolar Depression:

• Starting dose: 20 mg once daily (no titration required)
• Effective dose range: 20-120 mg daily 1
• Maximum recommended dose: 120 mg daily

For Pediatric Patients (10-17 years) with Bipolar Depression:

• Starting dose: 20 mg once daily
• Effective dose range: 20-80 mg daily
• Maximum recommended dose: 80 mg daily 1

Special Populations

Renal Impairment

• For moderate (CrCl: 30 to <50 mL/min) or severe (CrCl <30 mL/min) renal impairment:
  • Starting dose: 20 mg daily
  • Maximum dose: 80 mg daily 1

Hepatic Impairment

• For moderate (Child-Pugh Score = 7 to 9) hepatic impairment:
  • Starting dose: 20 mg daily
  • Maximum dose: 80 mg daily
• For severe (Child-Pugh Score = 10 to 15) hepatic impairment:
  • Starting dose: 20 mg daily
  • Maximum dose: 40 mg daily 1

Practical Tips for Taking Latuda

• Taking Latuda at bedtime may help patients sleep through initial side effects like nausea 2
• For once-daily medications like Latuda, the specific time of day is less important than maintaining consistency in the daily schedule 2
• To minimize common side effects (nausea, somnolence):
  • Take with a substantial meal (not just a small snack)
  • Be consistent with timing
  • Report persistent side effects to your healthcare provider 3

Common Side Effects to Be Aware Of

• Somnolence (drowsiness)
• Akathisia (restlessness)
• Nausea
• Parkinsonism (especially early in treatment) 3

Latuda has a favorable metabolic and cardiovascular profile compared to some other antipsychotics, with minimal weight gain and no significant impact on glucose, lipids, or QT interval prolongation 4, 5.