From the Research
Administration of IV Augmentin
To administer IV Augmentin (amoxicillin-clavulanate) 1.2g in Normal Saline (NS), the following points should be considered:
- The pharmacokinetics of intravenous Augmentin have been investigated, and the data found to fit a two-compartment model 1.
- A bolus injection of 1.2 g Augmentin was given to 8 healthy volunteers, and the serum concentrations of amoxicillin were increased in the presence of probenecid, but those of clavulanic acid were unaffected 1.
- An infusion over 30 min of 2.2 g Augmentin resulted in peak concentrations in excess of 100 micrograms/ml for amoxicillin and 14 micrograms/ml for clavulanic acid 1.
- The normal dosage for pediatric patients is in the range 100-200 mg/kg/day Augmentin, administered parenterally by short i.v. infusion in 3 or 4 divided doses 2.
- For adults, a pharmacokinetically enhanced tablet dosage form of amoxicillin/clavulanate 2000/125 mg twice daily has been developed for use in adult respiratory tract infection due to drug-resistant pathogens 3.
- Augmentin was used prophylactically in patients with acute surgical diseases of the abdominal cavity organs, with a dosage of 1.2 g intravenously with initial narcosis, followed by intravenous administration in a dose of 600 mg every 8 hours for 2-3 days 4.
Key Considerations
- The administration of IV Augmentin should be based on the patient's specific needs and medical condition.
- The dosage and administration schedule may vary depending on the patient's age, weight, and renal function.
- It is essential to follow the recommended dosage and administration guidelines to ensure the safe and effective use of IV Augmentin 1, 2, 3, 4.