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Last updated: September 19, 2025View editorial policy

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Differential Diagnosis for Soft Tissue Swelling and Ossifications around the PIP Joint of the Index

  • Single Most Likely Diagnosis
    • Bouchard's nodes: These are bony enlargements of the proximal interphalangeal (PIP) joints due to osteoarthritis, which can cause soft tissue swelling and ossifications around the affected joint.
  • Other Likely Diagnoses
    • Rheumatoid arthritis: This autoimmune disorder can cause inflammation and swelling of the joints, including the PIP joints, and may lead to ossifications and deformities over time.
    • Psoriatic arthritis: A type of arthritis that occurs in some people with psoriasis, causing joint pain, swelling, and stiffness, and can lead to bony growths and ossifications.
    • Trauma: Direct injury to the PIP joint can cause soft tissue swelling and, in some cases, lead to heterotopic ossification (the formation of bone in soft tissues).
  • Do Not Miss Diagnoses
    • Septic arthritis: A bacterial or fungal infection within the joint, which is a medical emergency requiring prompt treatment to prevent joint destruction and systemic complications.
    • Gout: A form of inflammatory arthritis characterized by sudden, severe attacks of pain, swelling, redness, and tenderness, often occurring at the base of the big toe but can affect other joints, including the PIP joints.
  • Rare Diagnoses
    • Tophaceous gout: A rare and severe form of gout where urate crystals form deposits (tophi) in the soft tissues, which can mimic ossifications.
    • Sarcoidosis: A condition in which inflammatory cells form lumps known as granulomas in various parts of the body, including the joints, though joint involvement is less common.
    • Osteochondroma: A type of benign bone tumor that can occur near the ends of bones, potentially causing soft tissue swelling and ossifications if it affects the area around the PIP joint.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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