Carpal Tunnel Syndrome: This condition is characterized by compression of the median nerve as it passes through the wrist, leading to pain, numbness, and weakness in the hand and wrist. Bilateral involvement is common, especially in individuals who perform repetitive tasks or have certain medical conditions.

Repetitive Strain Injury (RSI): Also known as work-related upper limb disorder, RSI can cause pain and weakness in the wrists due to repetitive movements or overuse.
Rheumatoid Arthritis: An autoimmune disorder that can cause inflammation and pain in multiple joints, including the wrists, leading to weakness and decreased function.
Osteoarthritis: Wear and tear of the joint cartilage can cause pain and stiffness in the wrists, although bilateral weakness is less common.

Guillain-Barré Syndrome: A rare autoimmune disorder that can cause rapid onset of muscle weakness, often starting in the lower extremities but can progress to involve the upper limbs, including the wrists.
Multiple Myeloma: A type of blood cancer that can cause bone pain, including in the wrists, and lead to weakness due to hypercalcemia or bone lesions.
Hypothyroidism: Severe cases can cause muscle weakness, including in the wrists, due to metabolic changes.

Amyotrophic Lateral Sclerosis (ALS): A progressive neurological disease that affects nerve cells in the brain and spinal cord, leading to loss of muscle control, including in the wrists.
Peripheral Neuropathy: Damage to the peripheral nerves can cause weakness, numbness, and pain in the wrists, often due to diabetes, vitamin deficiencies, or certain medications.
Kienböck's Disease: A rare condition characterized by the collapse of the lunate bone in the wrist, leading to pain and weakness.