Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: September 19, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for Hematoma and Bruising

Single Most Likely Diagnosis

  • Trauma: This is the most likely diagnosis, as hematoma and bruising are common results of physical injury, such as falls, accidents, or assaults. The presence of a hematoma indicates bleeding into the tissues, which is often caused by trauma.

Other Likely Diagnoses

  • Coagulopathy: Disorders that affect blood clotting, such as hemophilia or vitamin K deficiency, can lead to hematoma and bruising due to the body's inability to form proper blood clots.
  • Vascular Disorders: Conditions like vasculitis or blood vessel malformations can cause bleeding into the tissues, resulting in hematoma and bruising.
  • Medication Side Effects: Certain medications, such as anticoagulants (e.g., warfarin) or antiplatelet agents (e.g., aspirin), can increase the risk of bleeding and bruising.
  • Infection: Infections, such as sepsis or abscesses, can cause inflammation and bleeding, leading to hematoma and bruising.

Do Not Miss Diagnoses

  • Abuse or Neglect: It is crucial to consider the possibility of abuse or neglect, especially in vulnerable populations like children or the elderly, as hematoma and bruising can be signs of non-accidental trauma.
  • Cancer: Certain types of cancer, such as leukemia or lymphoma, can cause bleeding and bruising due to bone marrow suppression or coagulopathy.
  • Sepsis: Sepsis, a life-threatening condition caused by an overwhelming infection, can lead to bleeding and bruising due to disseminated intravascular coagulation (DIC).

Rare Diagnoses

  • Ehlers-Danlos Syndrome: A genetic disorder that affects connective tissue, leading to fragile blood vessels and increased risk of bleeding and bruising.
  • Pseudoxanthoma Elasticum: A rare genetic disorder that affects the elastic fibers in skin, eyes, and blood vessels, leading to easy bruising and bleeding.
  • Amyloidosis: A condition characterized by the deposition of abnormal proteins (amyloid) in various tissues, which can cause bleeding and bruising due to blood vessel damage.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.