What are the differential diagnoses (DDx) for headaches?

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Differential Diagnosis for Headaches

The following is a comprehensive differential diagnosis for headaches, categorized for clarity and emphasis on critical conditions.

  • Single Most Likely Diagnosis

    • Tension headache: This is the most common type of headache and is often related to stress, muscle tension, or poor posture. It is characterized by a band-like pressure around the forehead, back of the neck, or both.
    • Migraine: A frequent cause of headache, especially in younger individuals, characterized by unilateral, throbbing pain, often accompanied by nausea, vomiting, and sensitivity to light and sound.
  • Other Likely Diagnoses

    • Cluster headache: Known for severe, unilateral orbital or periorbital pain, often accompanied by autonomic symptoms like lacrimation and nasal congestion.
    • Sinus headache: Caused by inflammation or infection of the sinuses, leading to pain and pressure in the face, particularly in areas surrounding the sinuses.
    • Medication overuse headache: Occurs in individuals who frequently use headache medications, leading to a vicious cycle of headache and medication overuse.
    • Cervicogenic headache: Originates from the cervical spine and is often related to neck movement or posture.
  • Do Not Miss Diagnoses

    • Subarachnoid hemorrhage: A life-threatening condition caused by bleeding into the space surrounding the brain, often presenting with a sudden, severe headache (thunderclap headache).
    • Meningitis: Inflammation of the protective membranes covering the brain and spinal cord, which can be caused by infection and presents with headache, fever, and stiff neck.
    • Temporal arteritis: Inflammation of the blood vessels, particularly those in the temples, which can lead to blindness if not promptly treated.
    • Brain tumor: Although rare, can cause headaches due to increased intracranial pressure, often worse in the morning and associated with nausea and vomiting.
    • Acute angle-closure glaucoma: A medical emergency that causes severe eye pain, headache, and vision changes due to increased pressure in the eye.
  • Rare Diagnoses

    • Trigeminal neuralgia: Characterized by intense pain along a branch of the trigeminal nerve, often triggered by light touch.
    • Hypnic headache: A rare headache disorder that occurs only during sleep and wakes the patient.
    • Hemicrania continua: A persistent, one-sided headache with autonomic features, which is completely responsive to indomethacin.
    • Chiari malformation: A structural defect in the cerebellum that can cause headaches, often worsened by coughing or straining.
    • Idiopathic intracranial hypertension (IIH): Characterized by increased pressure within the skull without a detectable cause, often presenting with headache and vision changes.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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