Infant Dose of Gaviscon (Sodium Alginate)
The recommended dose of Gaviscon Infant (sodium alginate) for infants is 625 mg (one dose) mixed with 225 ml of formula or breast milk.
Dosing Guidelines
Gaviscon Infant is specifically formulated for infants with gastroesophageal reflux (GER) symptoms. The dosing should be administered as follows:
- Standard dose: 625 mg mixed with 225 ml of milk
- Administration frequency: After feedings, typically up to 6 times daily
- Age range: Suitable for infants from birth through infancy
Mechanism of Action
Gaviscon Infant works through a unique mechanism that differs from traditional antacids:
- Forms a gel-like barrier (raft) that floats on top of stomach contents
- Helps prevent reflux of acidic stomach contents into the esophagus
- Creates a physical barrier rather than neutralizing stomach acid
- Reduces reflux height in the esophagus 1
Efficacy Evidence
Research shows variable efficacy of Gaviscon Infant for treating GER in infants:
- Studies demonstrate that Gaviscon Infant significantly decreases acid reflux episodes detected by pH monitoring 2
- Reduces the number of reflux events reaching the proximal esophagus 2
- Decreases acid esophageal exposure (4.0% vs 7.6% without treatment) 2
- Some studies show only marginal benefits in reflux height reduction 3
Clinical Considerations
When prescribing Gaviscon Infant, consider these important factors:
- Compatibility: Works effectively with different milk formulations including extensively hydrolyzed, partially hydrolyzed, and amino acid formulas 1
- Onset of action: Raft formation occurs rapidly, often within seconds of dosing 4
- Duration: Effects can last several hours, providing longer-lasting relief than traditional antacids 4
- Safety profile: Generally favorable compared to H2 blockers and PPIs due to its non-systemic mechanism 2
Monitoring and Precautions
- Monitor for improvement in symptoms such as regurgitation, irritability, and feeding difficulties
- Assess for any adverse effects, though these are uncommon
- Consider alternative diagnoses if symptoms persist despite adequate treatment
- For persistent symptoms, further evaluation may be necessary to rule out other conditions such as cow's milk protein allergy
Common Pitfalls to Avoid
- Confusing formulations: Ensure you're using Gaviscon Infant specifically, not adult Gaviscon formulations
- Incorrect mixing: Always mix the recommended dose with the appropriate volume of milk
- Overreliance: Don't rely solely on medication without addressing feeding techniques and positioning
- Delayed referral: If symptoms persist despite treatment, consider referral to a pediatric gastroenterologist
Gaviscon Infant provides a non-systemic approach to managing infant reflux with a favorable safety profile compared to acid-suppressing medications.