Storage Guidelines for Duodopa (Carbidopa-Levodopa Intestinal Gel)
Duodopa should be stored in a refrigerator at 2-8°C (36-46°F) before use and can be kept at room temperature for up to 16 hours during active use.
Storage Requirements
Refrigerated Storage
- Store Duodopa cassettes in the original packaging in a refrigerator at 2-8°C (36-46°F)
- Protect from light
- Do not freeze
- Keep away from extreme temperatures that could affect potency
- Ensure refrigerator temperature is regularly monitored
Room Temperature Use
- Once removed from refrigeration, Duodopa can be kept at room temperature (20-25°C/68-77°F) for up to 16 hours during active use
- After this period, any unused medication should be discarded
- Do not return product to refrigeration after it has been kept at room temperature
Handling Precautions
Visual Inspection
- Before use, inspect the gel for any changes in color or consistency
- The gel should appear as a yellowish-white to slightly yellow opaque gel
- Do not use if the product shows signs of discoloration or precipitation
Transportation
- When transporting Duodopa, maintain the cold chain using appropriate cooling containers
- Avoid exposing the medication to temperatures outside the recommended range
- For patients traveling, use insulated medication carriers with cooling elements
Common Pitfalls to Avoid
- Temperature excursions: Avoid storing Duodopa in areas of the refrigerator prone to freezing (typically near the freezer compartment)
- Improper thawing: If accidentally frozen, do not use the product as freezing may affect drug stability and efficacy
- Extended room temperature exposure: Do not keep Duodopa at room temperature beyond the recommended 16 hours
- Direct sunlight: Keep medication away from direct sunlight, which can degrade the active ingredients
Special Considerations for Patients
- Patients using Duodopa pump systems should be educated about proper storage during daily use
- For travel, plan ahead to ensure continuous refrigeration is available or use appropriate cooling containers
- Always have a backup supply of medication stored properly in case of unexpected issues with the primary supply
Following these storage guidelines will help maintain the stability and efficacy of Duodopa, ensuring optimal therapeutic outcomes for patients with Parkinson's disease requiring this medication.