Differential Diagnosis for Blisters on One Side of the Body
- Single most likely diagnosis:
- Herpes Zoster (Shingles): This is the most likely diagnosis due to the characteristic unilateral distribution of blisters, typically affecting a single dermatome. The blisters are usually accompanied by pain, which can precede the rash.
- Other Likely diagnoses:
- Contact Dermatitis: Unilateral blisters can occur due to allergic or irritant contact dermatitis, depending on exposure to specific substances on one side of the body.
- Impetigo: A contagious skin infection that can cause blisters, which might start on one side of the body before spreading.
- Eczema (Dyshidrotic): Characterized by small blisters on the hands or feet, but can occasionally present unilaterally.
- Do Not Miss (ddxs that may not be likely, but would be deadly if missed):
- Staphylococcal Scalded Skin Syndrome (SSSS): Although more common in children, SSSS can cause widespread blistering and peeling, starting unilaterally, and is life-threatening.
- Toxic Epidermal Necrolysis (TEN): A severe skin condition usually triggered by medications, leading to blistering and peeling of the skin, which can start on one side of the body.
- Erythema Multiforme: An immune-mediated disorder that can cause target lesions and blisters, which, although rare, can be a sign of a severe underlying condition.
- Rare diagnoses:
- Bullous Pemphigoid: An autoimmune disease causing blistering of the skin, which can occasionally present unilaterally.
- Pemphigus Vulgaris: Another autoimmune disease leading to blistering, which is rare but can have a unilateral presentation.
- Linear IgA Disease: A rare autoimmune disorder characterized by blistering skin lesions, which can appear on one side of the body.