Electrolyte Content of K Phos Neutral 250 mg
K Phos Neutral 250 mg contains potassium and phosphate as its primary electrolytes.
Specific Electrolyte Content
K Phos Neutral 250 mg is a potassium phosphate supplement that contains:
- Potassium: Approximately 8 mEq per tablet 1, 2
- Phosphate: Approximately 155 mg (5 mmol) per tablet 1, 2
Clinical Significance of These Electrolytes
Potassium
- Essential electrolyte for maintaining proper cardiac rhythm, muscle function, and nerve conduction
- Typical daily requirement ranges from 40-100 mmol for an average adult 3
- Hypokalemia is a common complication in hospitalized patients, with prevalence ranging from 12-20%, and up to 25% in patients with kidney failure on prolonged dialysis 3
Phosphate
- Critical for energy metabolism, bone health, and cellular function
- Normal daily requirement is approximately 10-30 mmol for an average adult 3
- Hypophosphatemia is common in hospitalized patients, with prevalence up to 60-80% among ICU patients 3
- Particularly important for respiratory function, cardiac function, and overall patient outcomes 3
Monitoring Recommendations
When using K Phos Neutral or other phosphate/potassium supplements:
- Regular monitoring of electrolytes is essential, particularly in patients with kidney disease or those receiving kidney replacement therapy 3
- Electrolyte abnormalities are common in hospitalized patients (up to 65% cumulative incidence) 3
- For patients on parenteral nutrition, magnesium and phosphorus levels should be monitored every 1-2 days initially, then 1-2 times weekly 4
- For patients with chronic intestinal disorders, magnesium and phosphorus levels should be monitored every 2-3 months 4
Clinical Applications
K Phos Neutral is commonly used for:
Hypophosphatemia correction: Particularly important in critically ill patients where low phosphate levels can worsen respiratory failure and increase risk of prolonged mechanical ventilation 3
Management of absorptive hypercalciuria: Shown to reduce urinary calcium excretion from 277 ± 72 to 166 ± 43 mg per day in patients with absorptive hypercalciuria 2
Electrolyte replacement in patients with intestinal failure: Helps maintain phosphate balance in patients requiring parenteral nutrition 3
Potential Side Effects and Precautions
- Hyperphosphatemia: Excessive phosphate supplementation can lead to elevated serum phosphate levels 5
- Hypocalcemia: Phosphate administration can decrease serum calcium levels 6
- Hyperkalemia: Caution in patients with renal impairment or those taking potassium-sparing diuretics 4
- Metabolic alkalosis: Neutral phosphate administration can generate and maintain renal metabolic alkalosis 6
- Secondary hyperparathyroidism: Chronic phosphate administration may induce hyperparathyroidism 6
Dosing Considerations
The standard dosing of K Phos Neutral varies by indication, but clinical studies have used:
- 4 tablets twice daily (equivalent to approximately 1240 mg phosphate and 64 mEq potassium daily) for management of absorptive hypercalciuria 1, 2
Always adjust dosing based on regular monitoring of serum electrolyte levels to prevent imbalances.