Differential Diagnosis for AUB 5 days post last menstrual cycle

Single most likely diagnosis

• Ovulatory dysfunction: This is the most likely cause of abnormal uterine bleeding (AUB) 5 days post last menstrual cycle, as it can lead to irregular menstrual cycles and unpredictable bleeding patterns. Ovulatory dysfunction is common in women with polycystic ovary syndrome (PCOS), thyroid disorders, or those experiencing significant weight changes.

Other Likely diagnoses

• Hormonal imbalance: Fluctuations in estrogen and progesterone levels can cause AUB. This is often seen in women taking hormonal contraceptives, those with thyroid disorders, or during the perimenopausal period.
• Infection or inflammation: Pelvic inflammatory disease (PID), endometritis, or cervicitis can cause AUB due to inflammation and irritation of the reproductive organs.
• Uterine fibroids or polyps: These growths can cause irregular bleeding, especially if they are submucosal or intramural.

Do Not Miss (ddxs that may not be likely, but would be deadly if missed)

• Pregnancy complications: Ectopic pregnancy or spontaneous abortion can present with AUB and must be ruled out, especially if the patient is sexually active and not using contraception.
• Malignancy: Endometrial, cervical, or ovarian cancer can cause AUB, although these are less common causes.
• Coagulopathy: Bleeding disorders, such as von Willebrand disease or platelet function disorders, can cause AUB due to impaired coagulation.

Rare diagnoses

• Adenomyosis: A rare condition where endometrial tissue grows into the uterine wall, causing heavy or irregular bleeding.
• Uterine arteriovenous malformation: A rare vascular anomaly that can cause AUB due to abnormal blood flow.
• Systemic diseases: Certain systemic diseases, such as liver or kidney disease, can cause AUB due to coagulopathy or hormonal imbalances.