Squamous Cell Carcinoma (SCC): This is the most common type of oral cancer, often presenting as a large, ulcerative lesion on the jaw or other parts of the oral cavity. The size of the lesion (>2cm) and its location on the jaw increase the suspicion for SCC.

Oral Lymphoma: Although less common than SCC, lymphoma can present as a large oral lesion and should be considered, especially in immunocompromised patients.
Salivary Gland Tumors: Both benign (like pleomorphic adenoma) and malignant (such as mucoepidermoid carcinoma) salivary gland tumors can present as jaw lesions, especially if they originate from the minor salivary glands located throughout the oral cavity.
Keratoacanthoma: A rapidly growing, benign tumor that can mimic SCC clinically but is less aggressive and often resolves on its own.

Metastatic Disease: Although rare, metastases to the jaw from other primary cancers (e.g., breast, lung, or prostate cancer) can present as large lesions and would have significant implications for patient management and prognosis.
Giant Cell Tumor: Typically benign but locally aggressive, giant cell tumors can cause significant destruction of the jaw and should not be missed due to their potential for local recurrence and, rarely, malignant transformation.
Osteosarcoma: A primary bone malignancy that, although rare in the jaw, would be critical to diagnose early due to its aggressive nature and poor prognosis if not treated promptly.

Ameloblastoma: A rare, benign (but locally aggressive) odontogenic tumor that can present as a large jaw lesion, often associated with the mandible.
Carcinoid Tumor: Rarely, carcinoid tumors can metastasize to the oral cavity, including the jaw, and present as a large lesion.
Melanoma: Primary oral melanoma is rare and aggressive, often presenting as a pigmented lesion on the jaw or other parts of the oral cavity.