Is drawing 10 units from a reconstituted 60mg Retatrutide vial with 3mL of bacteriostatic water accurate for a 2mg weekly dose?

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Last updated: September 22, 2025View editorial policy

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Retatrutide Reconstitution and Dosing Calculation

Yes, drawing 10 units on a U-100 insulin syringe from a 60mg Retatrutide vial reconstituted with 3mL of bacteriostatic water will accurately deliver a 2mg dose.

Calculation Verification

When reconstituting a 60mg vial with 3mL of bacteriostatic water, the resulting concentration can be calculated as follows:

  • Total medication: 60mg
  • Total volume: 3mL
  • Concentration: 60mg ÷ 3mL = 20mg/mL

For a 2mg weekly dose:

  • Required volume = 2mg ÷ 20mg/mL = 0.1mL

Since a U-100 insulin syringe is calibrated with 100 units per 1mL:

  • 0.1mL = 10 units on a U-100 syringe

Reconstitution Process

  1. Start with a 60mg powder vial of Retatrutide
  2. Add 3mL of bacteriostatic water to the vial
  3. Gently swirl (don't shake) until completely dissolved
  4. The resulting solution will have a concentration of 20mg/mL

Administration Guidelines

  • Use a U-100 insulin syringe for accurate measurement
  • Draw exactly 10 units (0.1mL) for a 2mg dose
  • Administer subcutaneously once weekly
  • Rotate injection sites to prevent lipohypertrophy
  • Store reconstituted solution according to manufacturer guidelines

Important Considerations

  • Ensure proper aseptic technique during reconstitution
  • Verify the solution is clear and free of particles before administration
  • Maintain consistent timing of weekly injections for optimal efficacy
  • Refrigerate reconstituted medication unless otherwise specified by manufacturer
  • Monitor for common side effects such as gastrointestinal symptoms

This dosing calculation is mathematically sound and follows standard pharmaceutical principles for reconstitution and administration of injectable medications.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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