What are the differential diagnoses for chronic yellow diarrhea?

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Last updated: March 17, 2025View editorial policy

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Differential Diagnosis for Chronic Yellow Diarrhea

Single Most Likely Diagnosis

  • Giardiasis: This is a common cause of chronic diarrhea, especially if the patient has a history of travel or exposure to contaminated water. The yellow color of the diarrhea could be due to the presence of excess fat (steatorrhea), which is a hallmark of giardiasis.

Other Likely Diagnoses

  • Celiac Disease: An autoimmune reaction to gluten can cause chronic diarrhea, and the malabsorption of fats can lead to yellow, greasy stools.
  • Pancreatic Insufficiency: A deficiency in pancreatic enzymes can lead to malabsorption of fats, resulting in chronic yellow diarrhea.
  • Bile Salt Malabsorption: Conditions such as ileal resection or disease can lead to bile salt malabsorption, causing chronic diarrhea with a yellow or greasy appearance.

Do Not Miss Diagnoses

  • Whipple's Disease: A rare, systemic bacterial infection that can cause chronic diarrhea, malabsorption, and weight loss. If missed, it can lead to severe complications and death.
  • Lymphoma: Certain types of lymphoma, such as intestinal lymphoma, can cause chronic diarrhea and malabsorption. Early diagnosis is crucial for effective treatment.
  • Amyloidosis: A condition characterized by the deposition of abnormal proteins in various organs, including the gastrointestinal tract, which can cause chronic diarrhea and malabsorption.

Rare Diagnoses

  • Abetalipoproteinemia: A rare genetic disorder that affects the absorption of fats, leading to chronic diarrhea and malabsorption.
  • Chronic Intestinal Pseudo-Obstruction: A rare condition characterized by impaired intestinal motility, which can cause chronic diarrhea and malabsorption.
  • Eosinophilic Gastroenteritis: A rare condition characterized by eosinophilic infiltration of the gastrointestinal tract, which can cause chronic diarrhea and malabsorption.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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