From the Research
Liver Panel and Hypoalbuminemia
- A liver panel is ordered for hypoalbuminemia due to nutritional causes because hypoalbuminemia can be an indicator of liver dysfunction, as well as other conditions such as protein energy malnutrition, inflammation, and crystalloid overload 1.
- Albumin is a protein produced by the liver, and its concentration in plasma is a reflection of liver function, among other factors 2.
- In cases of hypoalbuminemia due to nutritional causes, a liver panel can help determine if liver dysfunction is also present, which can inform treatment decisions 3.
Albumin and Liver Function
- Albumin function is impaired in various liver diseases, including non-alcoholic fatty liver disease, viral hepatitis, cirrhosis, and liver failure 2.
- Impaired albumin function is associated with disease severity and prognosis, and may be a novel biomarker of early impairment in liver function 2.
- The concentration of albumin associated with normal function, or 'efficient albumin concentration', is an important factor in assessing liver function 2.
Clinical Significance of Albumin Measurement
- Serum albumin concentration is a strong prognostic indicator of morbidity and mortality, but its measurement can be problematic due to variations in measurement methods and the presence of microheterogeneity in albumin 4.
- The clinical significance of albumin microheterogeneity, such as oxidized albumin and glycoalbumin, should be considered when interpreting serum albumin levels 4.
- Albumin administration is most indicated in the management of cirrhosis complications, and fluid resuscitation or treatment of severe and refractory edema, especially in patients with hypoalbuminemia 5.