From the Guidelines
I do not recommend using losartan with Confin (Keratolytic agent) as there is no information available on the safety and efficacy of this combination. Losartan is an angiotensin II receptor blocker (ARB) used to treat high blood pressure and protect kidney function in certain conditions 1. If you're asking about combining losartan with a specific medication, please clarify the exact name of the second drug, as "Confin" is not a recognized medication in the provided evidence. Losartan does have several known drug interactions with medications like lithium, NSAIDs (such as ibuprofen), potassium supplements, and other blood pressure medications 1. These interactions can lead to increased side effects or reduced effectiveness. Always consult with your healthcare provider before combining losartan with any other medication to ensure safety and appropriate treatment.
Key Considerations
- Losartan is used to treat high blood pressure and protect kidney function in certain conditions 1.
- There is no information available on the safety and efficacy of combining losartan with Confin (Keratolytic agent) 1.
- Losartan has known drug interactions with medications like lithium, NSAIDs, potassium supplements, and other blood pressure medications 1.
- Consult with your healthcare provider before combining losartan with any other medication to ensure safety and appropriate treatment.
Recommendations
- Consult with your healthcare provider before combining losartan with any other medication.
- Monitor blood pressure and kidney function regularly while taking losartan 1.
- Be aware of potential drug interactions with losartan and take steps to minimize risks 1.
From the Research
Losartan and Confin (Keratolytic agent) Interaction
There is no direct evidence in the provided studies to suggest an interaction between losartan and Confin (Keratolytic agent).
Renal Function and Losartan
- Losartan may cause renal dysfunction in certain patients, particularly those with bilateral renal artery stenosis, severe congestive heart failure, and severe sodium and volume depletion 2.
- The ELITE trial showed a 10.5% incidence of losartan-induced renal dysfunction in elderly patients with congestive heart failure with no known underlying renal dysfunction 2.
- Losartan has been shown to reduce the incidence of doubling of serum creatinine, end-stage renal disease, or death in patients with type 2 diabetes mellitus and proteinuria 3, 4.
Losartan and Other Medications
- Losartan has been compared to ACE inhibitors in several studies, with some suggesting that losartan may have similar effects on kidney function 5, 3.
- Losartan has been used in combination with other antihypertensive medications, such as calcium-channel antagonists, diuretics, alpha-blockers, beta-blockers, and centrally acting agents 4.
Monitoring and Precautions
- Renal function should be monitored in patients taking losartan, particularly in those with underlying renal dysfunction 2, 6.
- Losartan should be used with caution in patients with risk factors for renal dysfunction, such as old age, preexisting chronic renal failure, stenosis of renal arteries, solitary kidney, and diuretic therapy 6.