Differential Diagnosis for a 0.5 cm Raised, Gray, Non-Tender, Smooth, Moist Lesion on Labia Major
- Single Most Likely Diagnosis
- Condyloma Lata (Secondary Syphilis): This condition is characterized by painless, moist, broad-based lesions that can appear on the genital area, including the labia majora. The description of the lesion being gray, smooth, and moist aligns with condyloma lata, making it a strong candidate for the single most likely diagnosis.
- Other Likely Diagnoses
- Genital Warts (Human Papillomavirus): Although typically described as verrucous or cauliflower-like, some genital warts can appear smooth and may be confused with other lesions. Their presence on the labia majora and the fact that they can be moist due to the genital environment make them a consideration.
- Molluscum Contagiosum: This viral infection causes small, pearly, or flesh-colored lesions that can appear anywhere on the body, including the genital area. While they are usually described as having a central depression, their smooth appearance could fit the given description.
- Do Not Miss Diagnoses
- Squamous Cell Carcinoma: Although less likely given the age and description, any new or changing lesion in the genital area warrants consideration of malignancy. Squamous cell carcinoma can present in various ways, including as a raised, smooth lesion.
- Basal Cell Carcinoma: Similar to squamous cell carcinoma, basal cell carcinoma is a concern for any new skin lesion, especially in sun-exposed areas or areas with high sun damage potential, though the labia majora might be less commonly involved.
- Rare Diagnoses
- Lymphogranuloma Venereum (LGV): This is a sexually transmitted infection caused by certain types of Chlamydia trachomatis. It can cause lesions, but these are more commonly associated with the primary stage of the disease and might not exactly match the description given.
- Granuloma Inguinale (Donovanosis): Characterized by beefy-red, highly vascular lesions that bleed easily, this condition is less likely given the description of the lesion as gray and non-tender. However, variations in appearance can occur, making it a rare but possible consideration.