From the Research
Interaction Between Alfuzosin and Doxazosin
- The studies provided do not directly address the interaction between alfuzosin and doxazosin when taken 24 hours apart 1, 2, 3, 4, 5.
- However, it is known that doxazosin has a relatively long plasma half-life, which allows for its antihypertensive activity to be maintained over 24 hours following a single oral dose 1.
- Alfuzosin, on the other hand, is a selective alpha(1)-adrenoceptor antagonist that is used to treat benign prostatic hyperplasia (BPH) and has a prolonged-release formulation that allows for once-daily dosing 2, 3.
- There is no evidence to suggest that alfuzosin and doxazosin interact with each other in a way that would prevent them from being taken 24 hours apart 1, 2, 3, 4, 5.
Pharmacokinetics and Pharmacodynamics
- Doxazosin is readily absorbed and has a high bioavailability, with a plasma half-life that allows for its antihypertensive activity to be maintained over 24 hours 1.
- Alfuzosin has a prolonged-release formulation that allows for once-daily dosing, with a drug release sustained over 20 hours 2, 3.
- The pharmacokinetic and pharmacodynamic properties of alfuzosin and doxazosin do not suggest any interactions that would prevent them from being taken 24 hours apart 1, 2, 3, 4, 5.
Clinical Studies
- Clinical studies have compared the efficacy and safety of alfuzosin and doxazosin in the treatment of BPH and hypertension, but none have addressed the specific question of taking alfuzosin 24 hours after doxazosin 1, 2, 3, 4, 5.
- One study compared the effects of doxazosin and terazosin on total International Prostate Symptom Score (IPSS) and maximum urinary flow rate (Qmax) in treating patients with LUTS, but did not address the interaction between alfuzosin and doxazosin 5.