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Last updated: September 23, 2025View editorial policy

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Differential Diagnosis for Nose Bleed

  • Single most likely diagnosis
    • Dry air or minor trauma: This is often the most common cause of nose bleeds, especially in dry environments or due to minor injuries to the nasal mucosa.
  • Other Likely diagnoses
    • Allergies: Allergic reactions can lead to nasal congestion and irritation, increasing the risk of a nose bleed.
    • Hypertension: High blood pressure can cause blood vessels in the nose to become fragile and prone to bleeding.
    • Nasal infections: Infections such as sinusitis or common colds can irritate the nasal passages and lead to bleeding.
    • Use of nasal decongestants: Overuse of nasal decongestants can dry out the nasal mucosa, making it more susceptible to bleeding.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Tumor: Although rare, a tumor in the nasal cavity or sinuses can cause recurrent or severe nose bleeds.
    • Bleeding disorder: Conditions such as hemophilia or von Willebrand disease can lead to prolonged or severe bleeding.
    • Vascular malformation: Abnormalities in blood vessel formation can cause recurrent or severe nose bleeds.
    • Foreign body: In children, the presence of a foreign body in the nose can cause bleeding and should be ruled out.
  • Rare diagnoses
    • Hereditary hemorrhagic telangiectasia: A genetic disorder characterized by abnormal blood vessel formation, which can lead to recurrent nose bleeds.
    • Granulomatosis with polyangiitis (formerly known as Wegener's granulomatosis): A rare autoimmune disorder that can cause inflammation and bleeding in the nasal passages.
    • Scurvy: A condition caused by vitamin C deficiency, which can lead to fragile blood vessels and nose bleeds.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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