What is the ICD (International Classification of Diseases) code for anal papilloma?

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ICD Code for Anal Papilloma

The ICD-10 code for anal papilloma is D12.9 (benign neoplasm of anus and anal canal, unspecified).

Understanding Anal Papillomas

Anal papillomas are benign growths that occur in the anal region and are primarily caused by human papillomavirus (HPV) infection, specifically low-risk HPV types 6 and 11, which account for approximately 90% of all genital warts 1, 2.

Key Characteristics:

  • Anal papillomas are also known as anal condyloma acuminatum or anal warts
  • They are the most commonly diagnosed sexually transmitted disease in the United States 2
  • They may be asymptomatic or present with:
    • Painless bumps
    • Itching
    • Discharge
    • Bleeding

Distinction from Anal Cancer

It's important to differentiate anal papillomas from anal cancer:

  • Anal papillomas are benign lesions primarily caused by low-risk HPV types 6 and 11
  • Anal cancer is predominantly associated with high-risk HPV types, especially HPV-16 and HPV-18 1
  • Approximately 84-97% of anal cancers are attributable to HPV infection 3

Risk Factors for Progression

While most anal papillomas do not progress to cancer, certain risk factors increase the likelihood of developing anal cancer:

  • HIV infection (15-35 fold increased risk) 3, 1
  • Immunosuppression following solid organ transplantation 3, 1
  • History of other HPV-related genital cancers 3
  • Smoking 3
  • Men who have sex with men, particularly if HIV-positive 1

Clinical Considerations

When documenting anal papillomas with the ICD-10 code D12.9, clinicians should be aware that:

  • Multiple lesions may be present and can extend into the anal canal or rectum 2
  • Patients with visible genital warts can be simultaneously infected with multiple HPV types, including both low-risk and high-risk types 1
  • Recurrence rates are high (approximately 30%) regardless of treatment method 1

Screening Considerations

For patients with anal papillomas who fall into high-risk categories, consider:

  • Anal cytology screening for early detection of anal intraepithelial neoplasia (AIN), which is a precursor to anal cancer 1, 4
  • Regular digital anorectal examinations for early detection of anal cancer 3

Remember that while anal papillomas themselves are benign, their presence indicates HPV infection and potentially increased risk for anal cancer in certain populations.

References

Guideline

Anal Cancer Risk and Prevention

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Anal condyloma acuminatum.

Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates, 2009

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Anal Intraepithelial Neoplasia and Squamous Cell Cancer of the Anus.

Clinics in colon and rectal surgery, 2018

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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