What is the differential diagnosis for a 55-year-old female with mild erythema of the collar area, without lesions, that is pruritic when scratched, with no improvement after treatment with hydrocortisone (hydrocortisone)?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: March 17, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for a 55-year-old Female with Mild Erythema of the Collar

  • Single most likely diagnosis
    • Contact dermatitis: This is a common condition that can cause erythema and itching, especially if the area is scratched. The lack of improvement with hydrocortisone does not rule out this diagnosis, as some cases may require more potent topical steroids or avoidance of the offending agent.
  • Other Likely diagnoses
    • Seborrheic dermatitis: This condition can cause erythema and itching, particularly in areas with high sebaceous gland activity, such as the neck. It may not respond to hydrocortisone, especially if the diagnosis is not typical.
    • Atopic dermatitis: Although less common in adults, atopic dermatitis can cause itching and erythema, especially if the area is scratched. The lack of response to hydrocortisone may indicate a need for more potent topical steroids or other treatments.
    • Irritant dermatitis: Similar to contact dermatitis, irritant dermatitis can cause erythema and itching due to exposure to irritating substances.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Cutaneous T-cell lymphoma (Mycosis fungoides): Although rare, this condition can cause erythema and itching, and it is essential to consider it in the differential diagnosis to avoid delayed diagnosis and treatment.
    • Cutaneous metastasis: In rare cases, cancer can metastasize to the skin, causing erythema and itching. This diagnosis is crucial to consider, especially in patients with a history of cancer.
  • Rare diagnoses
    • Dermatomyositis: This is an autoimmune condition that can cause erythema and itching, particularly on the neck and shoulders. It is essential to consider this diagnosis, especially if there are other systemic symptoms.
    • Pityriasis rubra pilaris: This rare condition can cause erythema and itching, particularly on the neck and other areas. It is essential to consider this diagnosis, especially if there are other characteristic symptoms, such as palmoplantar keratoderma.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.