What is the origin of the first documented case of autism?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: September 23, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

The First Documented Case of Autism

The first documented case of autism was described by Leo Kanner in 1943, who reported on 11 children with an apparently congenital inability to relate to other people but who were quite sensitive to change in the nonsocial environment. 1

Historical Context and Origin

Kanner's groundbreaking paper published in 1943 marked the first systematic description of what we now recognize as autism spectrum disorder (ASD). In this landmark publication, Kanner described 11 children who exhibited:

  • Marked impairment in social relatedness
  • Difficulties with communication and language
  • Unusual, repetitive, and apparently purposeless activities (stereotypies)
  • Profound sensitivity to changes in their environment
  • A stark contrast between their lack of interest in people versus normal infants' social interest 1

Kanner emphasized that these children had what appeared to be a "congenital inability" to form normal affective connections with others, distinguishing this condition from childhood psychosis or schizophrenia 1.

Timeline of Discovery

  • 1938: The first patient with autism was examined by Kanner 2
  • 1943: Kanner published his landmark paper describing the condition 1, 3
  • 1944: Hans Asperger published his work on what would later be called Asperger's syndrome 4

It's worth noting that while Kanner is widely acknowledged as the first to formally recognize and document autism, some historical analysis suggests he may have had knowledge of earlier work by Hans Asperger, who had begun studying similar presentations approximately ten years earlier 4. However, Kanner's 1943 paper is still considered the first formal documentation and systematic description of the condition.

Kanner's Original Observations

Kanner's original observations were remarkably insightful and many remain valid today:

  • He recognized the condition as neurodevelopmental in nature
  • He described these children as having "an innate inability to form the usual, biologically provided contact with people" 3
  • He noted patterns in parental behavior that later supported genetic theories
  • He emphasized the heterogeneity of presentation among affected children 3

Evolution of Understanding

Since Kanner's initial description in 1943, our understanding of autism has evolved significantly:

  • Initially considered a form of childhood psychosis, by the 1970s autism was recognized as a distinct condition 1
  • By 1980, autism was officially recognized as a diagnosis in DSM-III 1
  • The diagnostic criteria have expanded and evolved to recognize the spectrum nature of the condition
  • Current prevalence estimates suggest autism affects approximately 1 in 36-59 children 5
  • The condition is now understood to have strong genetic components with heritability estimated at approximately 90% 5

Historical Significance

Kanner's work was particularly influential because:

  • It was published in the United States where it gained prominence in child psychiatry 4
  • It clearly differentiated autism from other childhood conditions
  • It established a foundation for future research and clinical understanding
  • It recognized autism as a biological condition rather than a result of parenting

In contrast, Asperger's contemporaneous work, written in German during the Nazi era, remained largely unknown for nearly four decades 4.

Kanner's legacy continues to influence our understanding of autism, and his advocacy for treating each child as a unique individual remains a cornerstone of modern approaches to autism care and support 3.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Leo Kanner's Mention of 1938 in His Report on Autism Refers to His First Patient.

Journal of autism and developmental disorders, 2016

Research

Leo Kanner and autism: a 75-year perspective.

International review of psychiatry (Abingdon, England), 2018

Research

[Deconstructing Kanner].

Revista de neurologia, 2017

Guideline

Autism Spectrum Disorder

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.