How to Taper Off Trazodone 50mg
For trazodone 50mg, a gradual taper is recommended with dose reductions of 10% per month (or slower) to minimize withdrawal symptoms, rather than abrupt discontinuation. 1
Tapering Schedule for Trazodone 50mg
Step-by-Step Approach
Initial reduction: Decrease by 12.5mg (25% of dose) to 37.5mg
- Maintain this dose for 2-4 weeks
- Monitor for withdrawal symptoms
Second reduction: Decrease by another 12.5mg to 25mg
- Maintain for 2-4 weeks
- Continue monitoring for withdrawal symptoms
Final reduction: Decrease to 12.5mg
- Maintain for 2-4 weeks before complete discontinuation
Complete discontinuation after successful period at lowest dose
Managing Withdrawal Symptoms
Trazodone discontinuation may cause withdrawal symptoms due to its effects on the serotonergic system 2. Common withdrawal symptoms include:
- Insomnia
- Anxiety
- Irritability
- Headache
- Gastrointestinal discomfort
Adjunctive Medications for Withdrawal Management
If withdrawal symptoms occur during tapering, consider these short-term adjuncts 3:
- For insomnia: Alternative sleep aids (temporarily)
- For anxiety/irritability: Short-term use of gabapentin
- For gastrointestinal discomfort: Loperamide (with caution due to abuse potential)
Special Considerations
- Slower taper for long-term use: If you've been taking trazodone for more than a year, consider an even slower taper (5% reductions) 3
- Timing of doses: Take remaining doses at bedtime to minimize daytime sedation 4
- Monitor for mood changes: Watch for emergence of depression or anxiety symptoms during the taper 1
- Avoid abrupt discontinuation: This can lead to more severe withdrawal symptoms 1, 2
Non-Pharmacological Approaches
During the tapering process, implement these strategies to improve sleep:
- Practice good sleep hygiene
- Consider cognitive behavioral therapy for insomnia (CBT-I) 5
- Establish regular sleep-wake times
- Avoid caffeine, alcohol, and electronic screens before bedtime
When to Seek Medical Help
Contact your healthcare provider if you experience:
- Severe withdrawal symptoms that interfere with daily functioning
- Worsening mood or emergence of suicidal thoughts
- Inability to follow the tapering schedule due to withdrawal severity
This tapering approach balances the need to minimize withdrawal symptoms while safely discontinuing trazodone, prioritizing your overall well-being and quality of life.