From the Guidelines
NAD+ (nicotinamide adenine dinucleotide) may help improve mood, though research is still emerging. While no specific dosage recommendations exist for mood enhancement specifically, supplements typically range from 100-500mg daily. NAD+ plays a crucial role in cellular energy production and supports the function of sirtuins, proteins that regulate stress responses and may influence mood. As NAD+ levels naturally decline with age, supplementation might help restore optimal cellular function, potentially improving energy levels and mental clarity which can positively affect mood. Some people report improved mood, reduced anxiety, and better stress management when taking NAD+ supplements or receiving NAD+ therapy. However, these effects vary between individuals, and NAD+ should not replace prescribed treatments for mood disorders. The supplement works by supporting mitochondrial function and energy metabolism in brain cells, potentially enhancing neurotransmitter production and function. If considering NAD+ for mood support, start with lower doses and consult a healthcare provider, especially if taking medications or having existing health conditions.
Key Points to Consider
- NAD+ supplementation may have a positive effect on mood, but more research is needed to confirm its efficacy.
- The optimal dosage for mood enhancement is unknown, but typical ranges are between 100-500mg daily.
- NAD+ supports cellular energy production and sirtuin function, which may influence mood regulation.
- Individual results may vary, and NAD+ should not be used as a replacement for prescribed treatments for mood disorders.
- Consult a healthcare provider before starting NAD+ supplementation, especially if taking medications or having existing health conditions.
Relevant Evidence
The most recent and highest quality study on this topic is not directly related to NAD+ and mood disorders, but rather focuses on the treatment of major depressive disorder (MDD) with second-generation antidepressants 1. However, this study highlights the importance of considering alternative treatment options for MDD, which may include NAD+ supplementation. Other studies have investigated the use of omega-3 fatty acids 1 and second-generation antidepressants 1 in the treatment of depressive disorders, but more research is needed to fully understand the potential benefits and risks of NAD+ supplementation for mood support.
From the Research
Nicotinamide Adenine Dinucleotide (NAD) and Mood Disorders
- NAD is an essential pyridine nucleotide cofactor involved in various biological processes, including oxidative phosphorylation and DNA repair 2
- Research suggests that NAD supplementation may have a positive effect on mood disorders, particularly in reducing anxiety conditions and improving quality of life 2
Association between NAD and Mood Disorders
- A study found that antidepressants may lead to a decrease in niacin and NAD in patients with poor dietary intake, potentially exacerbating psychiatric problems 3
- Another study highlighted the importance of nutrition in mood disorders, suggesting that a healthy diet rich in fruits, vegetables, and whole grains may decrease the risk of mood disorders 4
Safety and Effectiveness of NAD Supplementation
- A systematic review found that NAD supplementation is safe and well-tolerated, with some side effects including muscle pain, nervous disorders, and headaches 2
- The review also found that NAD supplementation may improve health parameters, such as decreasing anxiety and maximum heart rate, and increasing muscle insulin sensitivity 2
Future Directions
- Further research is needed to investigate the clinical benefits of NAD supplementation in specific diseases and to determine the optimal dosage 2
- Additionally, studies should explore the potential interactions between NAD supplementation and other treatments for mood disorders, such as antidepressants and anti-inflammatory agents 3, 5