From the Guidelines
Administration of Fluconazole via PEG Tube
Fluconazole (Diflucan) can be administered via a percutaneous endoscopic gastrostomy (PEG) tube.
- The provided evidence does not directly address the administration of fluconazole via a PEG tube, but it discusses the general use and management of PEG tubes for enteral nutrition and medication administration 1.
- According to the ESPEN guidelines on artificial enteral nutrition, PEG tubes can be used for the administration of medications, and the tube should be flushed with water after medication administration to prevent clogging 1.
- While the evidence does not specifically mention fluconazole, it can be inferred that fluconazole can be administered via a PEG tube, as long as the tube is properly managed and flushed after administration.
- It is essential to follow the general measures for PEG tube care, including flushing the tube with water after medication administration, to prevent complications such as clogging or infection 1.
- The decision to administer fluconazole via a PEG tube should be made on a case-by-case basis, considering the individual patient's needs and the potential benefits and risks of this administration route.
From the Research
Administration of Fluconazole via PEG Tube
- Fluconazole can be administered via a feeding tube, as studies have shown that it is significantly absorbed when crushed, dissolved, and given via a nasogastric or feeding tube in intensive care unit patients 2, 3.
- The bioavailability of fluconazole administered via a feeding tube has been reported to be 77% 2 and 97.2% 3, indicating that it can be effectively absorbed through this route.
- PEG tubes are commonly used for long-term feeding, fluid, and medication administration in patients who are unable to swallow or eat and drink enough 4, 5, 6.
- While there are potential complications associated with PEG tube placement and use, such as peritonitis and perforation of the colon, these can be avoided or dealt with promptly with good nursing care 5, 6.
- There is no direct evidence in the provided studies that specifically addresses the administration of fluconazole via a PEG tube, but the studies on bioavailability via feeding tubes suggest that it is likely to be effective 2, 3.