Stevens-Johnson Syndrome (SJS)/Toxic Epidermal Necrolysis (TEN): This condition is characterized by widespread skin necrosis and detachment, often involving the mucous membranes, and can be triggered by medications or infections. The presentation of blisters on the penis, hands, and soles, along with potential mucosal involvement, makes SJS/TEN a leading consideration due to its severity and the need for immediate medical intervention.

Pemphigus Vulgaris: An autoimmune disease that causes blistering of the skin and mucous membranes. While it more commonly affects the mouth and can involve the skin, the distribution on the penis, hands, and soles could be consistent with pemphigus, especially if there's mucosal involvement.
Bullous Pemphigoid: Another autoimmune blistering disease that primarily affects the skin, with lesions often appearing on the arms, legs, and areas around the genitals. The presence of blisters on the hands and soles could fit this diagnosis, although genital involvement is less common.
Erythema Multiforme (EM): A skin condition characterized by target lesions, often triggered by infections or medications. While EM typically involves the skin and sometimes mucous membranes, its presentation can vary, and the involvement of the penis, hands, and soles could be seen in more severe forms.

Toxic Shock Syndrome: A life-threatening condition caused by bacterial toxins, often presenting with fever, rash, and multi-organ failure. The rash can include blistering, and while the distribution might not typically involve the penis, hands, and soles exclusively, the severity of the condition necessitates its consideration.
Staphylococcal Scalded Skin Syndrome (SSSS): Caused by staphylococcal toxins that strip the skin of its outer layer, leading to widespread blistering and peeling. This condition is more common in children but can occur in adults, especially those with compromised immune systems.

Paraneoplastic Pemphigus: A rare autoimmune disorder associated with underlying neoplasms, characterized by severe mucosal lesions and skin blistering. The involvement of the penis, hands, and soles could be part of the presentation, but the rarity and association with cancer make it a less common consideration.
Epidermolysis Bullosa Acquisita (EBA): A rare autoimmune disease that results in blistering of the skin, often at the sites of trauma. While it can involve the hands and feet, and potentially the genital area, its rarity and the specific nature of the blisters (which are typically more resistant to blistering than in other conditions) make it a less likely diagnosis.