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Last updated: September 24, 2025View editorial policy

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Differential Diagnosis for Urinary Retention

  • Single most likely diagnosis
    • Benign Prostatic Hyperplasia (BPH): This is a common condition in older men where the prostate gland enlarges, potentially blocking the flow of urine and leading to urinary retention.
  • Other Likely diagnoses
    • Urinary Tract Infection (UTI): Especially in men with underlying conditions such as diabetes or those with catheter use, UTIs can cause irritation and lead to urinary retention.
    • Neurogenic Bladder: Conditions affecting the nerves that control the bladder, such as diabetes, stroke, or spinal cord injuries, can lead to urinary retention.
    • Medication Side Effects: Certain medications, including anticholinergics, antihistamines, and some antidepressants, can cause urinary retention as a side effect.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Spinal Cord Compression: A medical emergency that can cause urinary retention among other symptoms, requiring immediate intervention.
    • Cauda Equina Syndrome: A condition where the nerves in the spinal canal are compressed, leading to urinary retention and potentially permanent nerve damage if not promptly treated.
    • Posterior Urethral Valves: A congenital condition in males that can cause obstructive uropathy and urinary retention, more commonly diagnosed in infancy but can be missed.
  • Rare diagnoses
    • Bladder Neck Contracture: A narrowing of the bladder neck that can cause obstructive urinary symptoms, including retention, often as a result of trauma, surgery, or inflammation.
    • Urethral Stricture: A narrowing of the urethra that can impede the flow of urine, leading to retention, often due to injury, instrumentation, or infection.
    • Prostate Cancer: Although less common than BPH, prostate cancer can also cause urinary retention by obstructing the urethra.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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