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Last updated: September 24, 2025View editorial policy

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Differential Diagnosis for a Lump in the Axilla

Single Most Likely Diagnosis

  • Lipoma: A benign tumor composed of fat tissue, which is the most common cause of a lump in the axilla. It is usually soft, mobile, and painless.

Other Likely Diagnoses

  • Cyst: Such as a sebaceous cyst or an epidermoid cyst, which can occur in the axilla and present as a lump.
  • Infected lymph node: Can occur due to bacterial or fungal infections, and may present as a painful lump in the axilla.
  • Cat scratch disease: Caused by Bartonella henselae, typically presents with a painful lymph node in the axilla after a cat scratch or bite.
  • Breast cancer metastasis: Although less common, breast cancer can metastasize to the axillary lymph nodes, presenting as a lump.

Do Not Miss Diagnoses

  • Breast cancer: A lump in the axilla could be a sign of breast cancer, especially if it is hard, fixed, and accompanied by other symptoms like nipple discharge or a breast lump.
  • Lymphoma: Both Hodgkin's and non-Hodgkin's lymphoma can present with lymphadenopathy in the axilla, which may be a sign of a more serious underlying condition.
  • Tuberculosis: Can cause lymphadenitis, presenting as a lump in the axilla, and is important to diagnose due to its infectious nature and need for specific treatment.

Rare Diagnoses

  • Sarcoma: A rare type of cancer that can occur in the soft tissues of the axilla, presenting as a lump.
  • Hygroma: A rare, benign tumor that can occur in the axilla, typically presenting as a soft, translucent lump.
  • Neurofibroma: A rare, benign tumor of the nerve tissue that can occur in the axilla, presenting as a lump.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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