What is the cause of a burning sensation in the soles of the feet?

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Last updated: March 18, 2025View editorial policy

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Differential Diagnosis for Heat Sensation in Soles

  • Single Most Likely Diagnosis
    • Neuropathy (diabetic or peripheral): This is often the most common cause of abnormal sensations in the feet, including heat, due to damage to the peripheral nerves.
  • Other Likely Diagnoses
    • Erythromelalgia: A condition characterized by burning pain, heat, and redness in the hands and feet, which can be primary or secondary to other conditions like myeloproliferative disorders.
    • Peripheral artery disease: Reduced blood flow to the feet can cause a variety of sensations, including heat, due to ischemia.
    • Gout or other inflammatory arthritis: Inflammation in the joints of the feet can cause sensations of heat.
    • Vitamin deficiencies (B12, vitamin D): Certain vitamin deficiencies can lead to neuropathic symptoms, including abnormal sensations in the feet.
  • Do Not Miss Diagnoses
    • Deep vein thrombosis (DVT): Although less common, DVT can cause heat sensation in the affected limb due to inflammation and clotting, and it's crucial to diagnose promptly due to the risk of pulmonary embolism.
    • Cellulitis or other infections: Infections of the skin and soft tissues can cause heat, redness, and pain, and require prompt antibiotic treatment.
    • Complex regional pain syndrome (CRPS): A condition characterized by intense burning or aching pain in the hands or feet after an injury, which can also present with heat sensation.
  • Rare Diagnoses
    • Fabry disease: A genetic disorder that can cause burning sensations in the hands and feet due to the accumulation of a particular type of fat in the body's cells.
    • Charcot-Marie-Tooth disease: A group of inherited disorders that affect the peripheral nerves, potentially causing a variety of sensations, including heat, in the feet.
    • Sjögren's syndrome: An autoimmune disorder that can cause neuropathy and lead to sensations of heat in the feet among other symptoms.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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