Intravenous Dimenhydrinate (Gravol) Administration Guidelines
For intravenous administration of dimenhydrinate (Gravol), each 50 mg dose must be diluted in 10 mL of 0.9% Sodium Chloride Injection and injected slowly over a period of 2 minutes. 1
Dosing Information
Adult Dosing
- Standard dose: 50 mg every 4 hours as needed for nausea/vomiting control
- Maximum dose: 100 mg every 4 hours may be given when drowsiness is not objectionable or is desirable
- Duration of effect: Approximately 4 hours per dose
Pediatric Dosing
- 1.25 mg/kg of body weight or 37.5 mg/m² of body surface area, administered four times daily
- Maximum daily dose: Should not exceed 300 mg daily
Administration Procedure
Preparation:
- Each 50 mg (1 mL) of dimenhydrinate must be diluted in 10 mL of 0.9% Sodium Chloride Injection
- Inspect solution for particulate matter and discoloration before administration
Administration Rate:
- Inject diluted solution over a period of 2 minutes
- Do not administer as a rapid IV push or bolus
Safety Considerations
Potential Adverse Effects
- Drowsiness (common)
- Dizziness
- Anticholinergic effects (dry mouth, blurred vision)
- Hypotension with rapid administration
Precautions
- Monitor vital signs during administration
- Be prepared to manage potential adverse reactions
- Use caution in patients with cardiac conditions, as rapid administration may affect heart rate
Important Caveats
- Dimenhydrinate has abuse potential due to its anticholinergic properties when taken in supratherapeutic doses 2
- High doses (100-200 mg hourly) have been reported to cause euphoria and calming effects 3
- During pregnancy, particularly labor, dimenhydrinate should be used with caution as IV administration of 100 mg has been associated with increased uterine activity and potential fetal heart rate changes 4
Alternative Administration
- If IV administration is not appropriate, dimenhydrinate can be administered intramuscularly at the same dosage (50 mg as needed for adults)
The FDA-approved administration guidelines specifically state that intravenous dimenhydrinate must be properly diluted and administered slowly over 2 minutes to minimize adverse effects and ensure patient safety.