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Differential Diagnosis for 50 yo Male with Jaundice, Abdominal Pain, and Nausea Vomiting

Single Most Likely Diagnosis

  • Cholelithiasis with Cholecystitis or Choledocholithiasis: This condition is a common cause of jaundice and abdominal pain in adults, especially when associated with nausea and vomiting. The presence of gallstones can obstruct the bile duct, leading to jaundice and pain.

Other Likely Diagnoses

  • Viral Hepatitis: Hepatitis A, B, or C can cause jaundice, abdominal pain, and nausea. The diagnosis would depend on the patient's exposure history and serological tests.
  • Alcoholic Hepatitis: Given the patient's age, alcoholic hepatitis is a possibility, especially if there's a history of alcohol abuse. It can cause jaundice, abdominal pain, and nausea.
  • Pancreatitis: Both acute and chronic pancreatitis can present with abdominal pain, nausea, vomiting, and jaundice if the pancreatic inflammation affects the bile duct.

Do Not Miss Diagnoses

  • Ascending Cholangitis: An infection of the bile duct, usually due to obstruction by gallstones. It's a medical emergency requiring prompt antibiotic treatment and possible drainage.
  • Hepatic Artery Aneurysm or Rupture: Although rare, it can cause abdominal pain and jaundice. It's a life-threatening condition that requires immediate intervention.
  • Budd-Chiari Syndrome: Thrombosis of the hepatic veins can cause abdominal pain, jaundice, and nausea. It's a rare condition but can be fatal if not treated promptly.

Rare Diagnoses

  • Primary Biliary Cholangitis (PBC): An autoimmune disease of the liver that can cause jaundice and abdominal pain. It's more common in women but can occur in men.
  • Primary Sclerosing Cholangitis (PSC): A chronic liver disease that leads to scarring and narrowing of the bile ducts, causing jaundice and abdominal pain. It's associated with inflammatory bowel disease.
  • Hepatocellular Carcinoma: Although rare, liver cancer can cause jaundice, abdominal pain, and nausea, especially in patients with underlying liver disease.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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