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Last updated: September 25, 2025View editorial policy

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Differential Diagnosis for Pain Inner Canthus Both Eyes

  • Single most likely diagnosis
    • Dry eye syndrome: This condition is a common cause of eye discomfort and pain, especially in the inner canthus area, due to insufficient tear production or poor tear quality.
  • Other Likely diagnoses
    • Blepharitis: Inflammation of the eyelids can cause pain and discomfort in the inner canthus, often associated with redness, itching, and swelling.
    • Conjunctivitis: Infection or inflammation of the conjunctiva can lead to pain and discomfort in the eyes, including the inner canthus area.
    • Sinusitis: Sinus infections can cause referred pain to the eyes, including the inner canthus, due to the proximity of the sinuses to the orbital area.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Orbital cellulitis: A serious infection of the orbital tissues that can cause severe pain, swelling, and vision changes, requiring prompt medical attention.
    • Cavernous sinus thrombosis: A rare but life-threatening condition that can cause pain and swelling in the eyes, including the inner canthus, due to a blood clot in the cavernous sinus.
    • Temporal arteritis: Inflammation of the temporal arteries can cause severe headaches, jaw pain, and eye pain, including the inner canthus, and can lead to vision loss if left untreated.
  • Rare diagnoses
    • Sjögren's syndrome: An autoimmune disorder that can cause dry eye syndrome, but also other systemic symptoms, and can be associated with pain in the inner canthus area.
    • Trigeminal neuralgia: A rare condition that affects the trigeminal nerve, causing severe, stabbing pain in the face, including the eyes and inner canthus area.
    • Ocular migraine: A rare condition that can cause pain and visual disturbances, including pain in the inner canthus area, often accompanied by migraine headaches.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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