From the Research
NAD+ (nicotinamide adenine dinucleotide) injections can cause diarrhea as a side effect in some individuals, as evidenced by the potential of various drugs to disrupt gastrointestinal function and cause diarrhea 1.
Causes and Mechanisms
The exact mechanism by which NAD+ injections cause diarrhea is not well understood, but it is thought to be related to the alteration of gut microbiota and digestive processes. When administered intravenously or intramuscularly, NAD+ increases cellular energy production, which can lead to a rapid metabolic change that disrupts normal gastrointestinal function.
Management and Prevention
To minimize the risk of diarrhea, patients can start with lower doses of NAD+ (such as 250-500mg) and gradually increase to therapeutic levels (often 1000-1500mg per session) 2. Staying well-hydrated before and after treatment can help manage symptoms. Taking probiotics may also help maintain gut flora balance during NAD+ therapy. If diarrhea persists or becomes severe, the treatment schedule should be adjusted or temporarily discontinued after consulting with a healthcare provider.
Treatment Options
In cases where diarrhea becomes severe, treatment options such as antimotility agents (e.g., loperamide) or antimicrobial therapy (e.g., azithromycin, fluoroquinolones, and rifaximin) may be considered 3. However, the use of these agents should be judicious and based on the severity of the diarrhea and the individual patient's needs.
Key Considerations
- Diarrhea is a potential side effect of NAD+ injections
- Starting with lower doses and gradually increasing can help minimize the risk of diarrhea
- Staying well-hydrated and taking probiotics can help manage symptoms
- Severe diarrhea may require adjustment or temporary discontinuation of treatment
- Antimotility agents and antimicrobial therapy may be considered in cases of severe diarrhea 2, 3