From the Research
Methamphetamine withdrawal symptoms typically include intense cravings, depression, anxiety, fatigue, and disturbed sleep, and can be managed with medications such as bupropion, modafinil, benzodiazepines, and antipsychotics, in combination with behavioral therapy and support groups. The symptoms of methamphetamine withdrawal can be severe and may include:
- Intense cravings
- Depression
- Anxiety
- Fatigue
- Disturbed sleep According to a study published in 2024 1, a novel treatment protocol for methamphetamine withdrawal was found to be feasible, tolerable, and effective in reducing the intensity and duration of withdrawal symptoms. The protocol included pharmacological interventions such as ascorbic acid, antipsychotics, and sedatives, as well as behavior-based interventions. Another study published in 2019 2 found that bupropion and buprenorphine were effective in reducing methamphetamine cravings, with buprenorphine being superior to bupropion. However, the most recent and highest quality study 1 suggests that a comprehensive approach combining medication with behavioral therapy and support groups provides the best chance for successful recovery from methamphetamine addiction. Medications that may be used to manage symptoms of methamphetamine withdrawal include:
- Bupropion (Wellbutrin) at 150-300mg daily to reduce cravings and depression
- Modafinil (Provigil) at 200mg daily to address fatigue and cognitive issues
- Benzodiazepines like diazepam (5-10mg) or lorazepam (1-2mg) for short-term use to manage anxiety and agitation
- Antipsychotics like quetiapine (25-100mg) to manage psychosis or severe agitation
- Sleep aids like trazodone (50-100mg) or mirtazapine (15-30mg) to manage sleep disturbances. It is essential to note that medical supervision is crucial during withdrawal, and a comprehensive approach combining medication with behavioral therapy and support groups provides the best chance for successful recovery from methamphetamine addiction.