From the FDA Drug Label
The mean (range) time to reach peak concentration (tmax) was 7. 33 (1 – 24) hours. Due to buprenorphine elimination being faster than absorption from the skin, ZORBIUM exhibits flip-flop pharmacokinetics where the absorption determines its terminal half-life (mean 64.9 hours [range 39.1 – 85.7 hours]).
The time to reach steady state with the Butrans (buprenorphine) patch is not directly stated in the provided text. However, based on the terminal half-life of 64.9 hours, it can be estimated that it may take around 4-5 days to reach steady state, assuming a typical pharmacokinetic profile where steady state is achieved after 4-5 half-lives. However, this is an estimation and not a direct answer from the label. 1
From the Research
Butrans patches typically reach steady state blood levels within 48 hours of the first application, as demonstrated in a study published in the Journal of Pain and Symptom Management 2. When you first apply a Butrans patch (buprenorphine transdermal system), the medication gradually begins to be absorbed through your skin and into your bloodstream. During the initial application period, blood levels of buprenorphine slowly increase until they reach a consistent concentration. Once steady state is achieved, the drug levels remain relatively stable as long as patches are changed according to the prescribed schedule, which is usually every 7 days. It's essential to follow your doctor's instructions for patch application and replacement to maintain consistent pain relief. The time to steady state may vary slightly between individuals based on factors such as skin type, body temperature, and placement location. Patients should be aware that full pain relief may not occur until steady state is reached, and they should continue taking any prescribed breakthrough pain medication as directed during this initial period.
Some key points to consider:
- The study published in the Journal of Pain and Symptom Management 2 found that steady-state plasma concentrations were reached within 48 hours of the first application of the Butrans patch.
- The Butrans patch is designed to provide continuous delivery of buprenorphine for sustained analgesic efficacy with reduced adverse events compared to other modes of administration.
- Patients should be monitored for any adverse events, and the patch should be applied and replaced according to the prescribed schedule to maintain consistent pain relief.
Overall, the Butrans patch is an effective treatment option for managing chronic pain, and reaching steady state within 48 hours of the first application is a crucial aspect of its efficacy.