Peridex (Chlorhexidine Gluconate) Mouthwash Concentration and Dosing
Peridex (chlorhexidine gluconate) mouthwash is available as a 0.12% concentration solution and should be used as a 15 mL rinse twice daily for 30-60 seconds after brushing and flossing. 1, 2
Concentration
- Peridex contains 0.12% chlorhexidine gluconate solution 2
- This is different from the 0.2% concentration that is commonly used in some countries outside the United States 3
- The commercially available product (Peridex) contains the 0.12% concentration, which has been shown to be effective in clinical studies 2
Dosing Instructions
- Volume: 15 mL (approximately half a capful) per use
- Frequency: Twice daily (morning and evening)
- Duration: Rinse for 30-60 seconds
- Timing: Use after brushing and flossing, preferably at least 30 minutes after brushing
- Expectoration: Spit out after rinsing; do not swallow 2, 4
Clinical Efficacy
- Studies show significant reductions in:
- Plaque index (64.9% reduction)
- Gingival inflammation (60.0% reduction)
- Gingival bleeding (77.2% reduction) 2
- Particularly effective for:
- Patients with gingivitis
- Orthodontic patients
- Post-periodontal procedures
- Prevention of dry socket after oral surgery (56% reduction) 5
Common Side Effects and Management
- Tooth staining (reported by 77% of dentists as a major patient concern) 3
- Taste alterations (12% of patients report bitter taste) 3
- Oral irritation and soreness (6% of patients) 3
- Management: Discontinuation of the mouthwash and dental prophylaxis usually resolves these issues 4
Important Precautions
- Do not swallow the solution as systemic toxicity can occur 6
- Avoid eating or drinking for at least 30 minutes after use to maximize effectiveness
- May temporarily affect taste perception 4
- Not recommended for long-term continuous use due to side effects like staining
- Consider diluting 0.2% chlorhexidine by up to 50% if soreness occurs 1
Special Considerations
- Higher risk of adverse events in patients with BMI > 30 4
- May be used in conjunction with other oral care products for specific conditions like Stevens-Johnson syndrome 1, 7
- For patients experiencing soreness, a reduced concentration may be used 1
Chlorhexidine mouthwash is a prescription product in the United States but has been available over-the-counter in some countries for decades with a good safety profile when used as directed 3.