What are alternative antidepressant options to Wellbutrin (bupropion) for a patient who does not tolerate it?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: September 25, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Related Questions

What is the comparison between Auvelity (dextromethorphan-bupropion) and Wellbutrin (bupropion) for treating major depressive disorder?
How to manage a patient with Functional Neurological Disorder (FND) dissociation episodes who is taking Auvelity (dextromethorphan/bupropion)?
Is dextromethorphan/bupropion a suitable first-line treatment option for a patient with major depressive disorder (MDD) who has no prior treatment history?
What is the best approach to taper Caplyta (lumateperone) in a patient with bipolar disorder, who has a history of severe reactions to other mood stabilizers and suicidal thoughts, and is currently stable on Caplyta, Auvelity (dextromethorphan and bupropion), and Prazosin, with only 3 days of medication left due to insurance issues?
What is the recommended treatment protocol for Auvelity (dextromethorphan-bupropion) in adults with major depressive disorder?
What is the role of Diosmin in the treatment of hemorrhoids?
What medication change is recommended for a patient on Latuda (lurasidone) 40 mg daily, Buspar (buspirone) 20mg BID, and Trintellix (vortioxetine) 20 mg daily who is still experiencing depression?
What is the management for a diphtheria case?
What is the recommended NPH (Neutral Protamine Hagedorn) insulin dose for an 81 kg liver transplant patient receiving a 3rd dose of methylprednisolone (methylprednisolone) 1000 mg?
Can I get the shingles vaccine if I have ocular shingles with persistent symptoms but no open lesions?
Would sertraline, Exelon patch (rivastigmine), or memantine be effective for managing depression and agitation in an elderly woman with vascular dementia?

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.