Can you take 10 mg of Cialis (tadalafil) once daily?

Tadalafil 10 mg Once Daily Dosing

Yes, you can take 10 mg of Cialis (tadalafil) once daily, but this is not the FDA-approved daily dose for most indications. The appropriate daily dose depends on your specific medical condition and treatment goals.

FDA-Approved Dosing Guidelines for Tadalafil

For Erectile Dysfunction (ED):

• As-needed dosing: 10 mg is the recommended starting dose, which may be increased to 20 mg or decreased to 5 mg based on efficacy and tolerability 1
• Once-daily dosing: The recommended starting dose is 2.5 mg, which may be increased to 5 mg based on response 1

For Benign Prostatic Hyperplasia (BPH):

• Once-daily dosing: 5 mg is the recommended dose 1

For Combined ED and BPH:

• Once-daily dosing: 5 mg is the recommended dose 1

Safety Considerations with 10 mg Daily Dosing

Taking 10 mg daily exceeds the FDA-approved once-daily dosage of 2.5-5 mg for erectile dysfunction and 5 mg for BPH. This higher daily dose may:

1. Increase risk of side effects: Common side effects include headache, flushing, dyspepsia, nasal congestion, back pain, and myalgia 2

2. Potentially unnecessary exposure: Research shows that 5 mg daily is effective for most patients with ED 3, 4

Clinical Evidence for Once-Daily Dosing

Research supports that once-daily tadalafil at 5 mg:

• Provides sustained therapeutic plasma levels due to tadalafil's 17.5-hour half-life 3
• Allows for spontaneous rather than scheduled sexual activity 2
• Demonstrates significant improvement in erectile function in men with ED 3
• Shows long-term safety and efficacy for up to 2 years of continuous use 4

Special Considerations

Renal Impairment:

• Moderate impairment (CrCl 30-50 mL/min): Starting dose of 2.5 mg for once-daily use, with potential increase to 5 mg based on individual response 1
• Severe impairment (CrCl <30 mL/min): Once-daily dosing is not recommended 1

Hepatic Impairment:

• Mild to moderate impairment: Use with caution
• Severe impairment: Once-daily dosing is not recommended 1

Recommendation

If you're considering once-daily tadalafil:

1. Start with the FDA-approved dose of 2.5-5 mg for ED or 5 mg for BPH
2. Consult with your healthcare provider before taking 10 mg daily, as this exceeds recommended daily dosing
3. Consider the as-needed option of 10 mg if appropriate for your condition

Taking 10 mg daily without medical supervision may expose you to unnecessary side effects without additional therapeutic benefit for most patients.