Is Group B Streptococcus (GBS) susceptible to doxycycline?

From the Research

Antibiotic Susceptibility of Group B Streptococcus

• Group B Streptococcus (GBS) is generally susceptible to beta-lactam antibiotics, such as penicillin and ampicillin 1, 2, 3, 4, 5
• However, there is increasing resistance to second-line antibiotics, including erythromycin and clindamycin 1, 2, 4, 5
• The susceptibility of GBS to doxycycline is not explicitly mentioned in the provided studies
• GBS remains susceptible to vancomycin, although there have been rare cases of vancomycin resistance reported 2

Resistance Patterns

• Erythromycin resistance in GBS isolates has been reported to be as high as 32.3% 1 and 25.6% 4
• Clindamycin resistance in GBS isolates has been reported to be as high as 17.5% 1 and 12.7% 4
• Resistance to erythromycin and clindamycin is often associated with specific serotypes, such as serotype V 1, 4

Treatment Implications

• Penicillin remains the treatment of choice for GBS infections, due to its high efficacy and low resistance rates 1, 2, 3, 4, 5
• For patients allergic to penicillin, alternative antibiotics such as clindamycin or vancomycin may be considered, although resistance rates should be taken into account 1, 2, 4, 5