What are the guidelines for interpreting an MRI (Magnetic Resonance Imaging) reading?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: September 26, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Guidelines for Interpreting an MRI Reading

MRI interpretation requires a structured approach with standardized reporting to ensure accurate diagnosis and effective communication between radiologists and referring clinicians.

MRI Report Structure

A comprehensive MRI report should include the following key components 1:

1. MRI Technique

  • Brief description of anatomical area covered (brain, spinal cord, optic nerve, etc.)
  • Field strength used (minimum 1.5T recommended) 1
  • Slice thickness (3mm with no gap between slices is optimal) 1
  • Type and dose of contrast agent if used
  • Sequences performed (T1, T2, FLAIR, DWI, etc.)

2. Findings

The findings section should include 1:

  • Systematic description of all imaging findings using standardized terminology
  • Lesion characteristics:
    • Number and topography
    • Size and shape
    • Signal characteristics across different sequences
    • Enhancement patterns if contrast was used
    • Qualitative assessment of lesion load
    • Brain atrophy assessment (if applicable)

3. Conclusion

The conclusion should 1:

  • Provide a clear radiological interpretation related to the clinical problem
  • Identify typical or atypical findings
  • Offer differential diagnosis when appropriate
  • Indicate evidence of disease activity or progression (in follow-up scans)
  • Note any incidental or unexpected findings, classified as clinically relevant or irrelevant

Specific Guidelines by Anatomical Region

Brain MRI

  • T2-FLAIR is optimal for lesion detection in the brain 1
  • Confirm lesions on multiple planes to avoid artifacts 1
  • For multiple sclerosis evaluation, look for lesions in characteristic regions (periventricular, juxtacortical, infratentorial) 1
  • White matter lesions should be carefully evaluated, especially in patients >50 years or with vascular risk factors 1

Spinal Cord MRI

  • T2-weighted sequences are preferred over T2-FLAIR for spinal cord imaging 1
  • Sagittal STIR can improve contrast-to-noise ratio but is susceptible to flow-related artifacts 1
  • Additional axial T2-weighted images should be performed to verify changes seen in the sagittal plane 1

Oncological MRI

For cancer screening or evaluation, the ONCO-RADS system provides a structured approach 1:

  • Categorize findings from 1-5 based on likelihood of malignancy
  • ONCO-RADS 1: Normal finding
  • ONCO-RADS 2: Benign finding highly likely
  • ONCO-RADS 3: Benign finding likely
  • ONCO-RADS 4: Malignant finding likely
  • ONCO-RADS 5: Malignant finding highly likely

Competency Requirements

Proper MRI interpretation requires 2:

  • Understanding of MRI physics and scanning principles
  • Knowledge of contrast enhancement techniques
  • Familiarity with multiple pulse sequences (T1, T2, STIR, DWI)
  • Recognition of normal anatomy, variants, and pathological conditions
  • Ability to identify false-positive and false-negative findings

Follow-up MRI Guidelines

For monitoring disease progression (e.g., in multiple sclerosis) 1:

  • Contrast-enhanced T1-weighted and T2-weighted scans to reveal inflammation and new/enlarging lesions
  • MRI subtraction techniques to facilitate detection of new lesions across serial scans
  • Follow-up scans at least annually, or more frequently (every 3-4 months) for patients requiring enhanced pharmacovigilance

Common Pitfalls to Avoid

  1. Inadequate technique: Ensure appropriate sequences for the clinical question are performed 1
  2. Misinterpretation of artifacts: Confirm findings on multiple sequences and planes 1
  3. Incomplete evaluation: Systematically review all anatomical regions included in the scan 1
  4. Inconsistent terminology: Use standardized terminology for clear communication 1
  5. Failure to correlate with clinical information: Always interpret findings in the clinical context 1

Structured Reporting Recommendations

Structured reporting improves communication and clinical decision-making 1:

  • Present information in a standardized format
  • Include relevant clinical data
  • Use clear, consistent terminology
  • Integrate technical parameters
  • Provide definitive conclusions with appropriate recommendations for follow-up

By following these guidelines, radiologists and clinicians can ensure accurate interpretation of MRI studies, leading to improved patient care and outcomes.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

MRI Interpretation Guidelines

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.