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Differential Diagnosis for Whitish Papules on the Scrotum

Single Most Likely Diagnosis

  • Fordyce spots: These are small, whitish or yellowish papules that can appear on the scrotum, penis, or vulva. They are caused by the visibility of sebaceous glands and are completely benign, often requiring no treatment.

Other Likely Diagnoses

  • Seborrheic keratoses: These are benign growths that can appear as whitish or brownish papules on the scrotum. They are very common and generally do not require treatment unless they become irritated or for cosmetic reasons.
  • Molluscum contagiosum: This is a viral infection that causes small, pearly, or flesh-colored bumps. The bumps can appear anywhere on the body, including the scrotum, and are contagious.
  • Eczema (atopic dermatitis): This condition can cause papules and is often associated with itching. It can appear on the scrotum and may require treatment with topical corticosteroids or other medications.

Do Not Miss Diagnoses

  • Squamous cell carcinoma: Although rare, this type of skin cancer can present as a firm, whitish papule on the scrotum. Early detection is crucial for effective treatment.
  • Extramammary Paget's disease: This is a rare skin cancer that can appear in the genital area, including the scrotum, often as a whitish or reddish patch or papule. It requires prompt medical attention.

Rare Diagnoses

  • Lichen nitidus: A rare skin condition characterized by tiny, shiny, flat-topped bumps that can appear on the scrotum among other areas. It's usually harmless and may resolve on its own.
  • Lichen sclerosus: This condition can cause white, patchy skin that's thinner than normal, and it may appear on the scrotum. It can be itchy and painful, and treatment is often necessary to prevent scarring.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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