Differential Diagnosis for Jelly-like Fluid in Blister

• Single most likely diagnosis
  • Burn or Scald: The presence of a jelly-like fluid in a blister is highly suggestive of a burn or scald injury. This type of fluid, also known as serum or exudate, accumulates as a result of the body's response to the injury, aiming to protect the damaged skin and promote healing.
• Other Likely diagnoses
  • Insect Bite or Sting: Certain insect bites or stings can cause blisters filled with a jelly-like fluid, especially if there's an allergic reaction involved.
  • Contact Dermatitis: Severe cases of contact dermatitis, particularly those caused by irritants or allergens, can lead to blister formation with fluid accumulation.
  • Friction Blister: While typically filled with clear fluid, in some cases, especially if infected, friction blisters can have a more turbid or jelly-like appearance.
• Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
  • Necrotizing Fasciitis: Although rare, this severe bacterial infection can cause blisters with fluid that may appear jelly-like due to the necrotic tissue and infection. It's a medical emergency requiring immediate attention.
  • Gas Gangrene: Another severe infection that can lead to blister formation with a foul-smelling, possibly jelly-like fluid due to the production of gas by the bacteria.
• Rare diagnoses
  • Epidermolysis Bullosa: A group of genetic conditions that result in fragile skin and blisters. While not typically described as having jelly-like fluid, the blisters can have various appearances.
  • Bullous Pemphigoid: An autoimmune disease that causes blistering of the skin. The fluid within these blisters can sometimes appear more turbid or jelly-like, especially in the presence of infection.