From the FDA Drug Label
Isotretinoin capsules should be administered with a meal (see PRECAUTIONS, Information for Patients). The recommended dosage range for isotretinoin capsules is 0.5 to 1 mg/kg/day given in two divided doses with food for 15 to 20 weeks. Failure to take isotretinoin capsules with food will significantly decrease absorption.
The optimal time to take isotretinoin (Accutane) is with a meal, in two divided doses. This is to ensure adequate absorption of the medication. The specific timing of the doses is not specified, but it should be taken with food to maximize absorption 1.
From the Research
The optimal time to take isotretinoin is with a meal containing fat, typically with your largest meal of the day, to increase absorption by up to 50% and improve effectiveness, as supported by the most recent and highest quality study 2.
Key Considerations
- Taking isotretinoin with food, especially fatty food, significantly increases its absorption, making the medication more effective.
- Most dermatologists recommend taking the daily dose with dinner or splitting the dose between breakfast and dinner if you're on a twice-daily regimen.
- The standard treatment course typically lasts 15-20 weeks (about 4-5 months), with dosing usually based on body weight (0.5-1 mg/kg/day).
- It's crucial to take isotretinoin consistently at the same time each day to maintain steady blood levels.
- Never take a double dose to make up for a missed one.
Important Safety Information
- Since isotretinoin can cause severe birth defects, female patients must use two forms of effective contraception and participate in pregnancy monitoring programs.
- Common side effects include dry lips, skin, and eyes, which can be managed with moisturizers and lip balm.
- Taking the medication with food not only improves absorption but may also help reduce potential gastrointestinal side effects.
Additional Guidance
- Low-dose isotretinoin (0.5 mg/kg/day for 1 week every 4 weeks for 6-months) could be effective and even comparable with high or optimal doses, as shown in a systematic review 2.
- Fixed-dose 10 mg daily isotretinoin treatment for acne vulgaris has been found to be safe with a low relapse rate, as reported in a prospective study 3.
- However, it's essential to be aware of the potential side effects of isotretinoin, including premature epiphyseal closure, especially in pediatric populations, as highlighted in a literature review 4.