What are the uses of a 200 mg tablet?

Uses of 200 mg Tablet

A 200 mg tablet is most commonly used for the treatment of cutaneous and lymphocutaneous sporotrichosis, with itraconazole 200 mg daily being the recommended standard therapy for 3-6 months. 1

Primary Uses of 200 mg Tablets

Antifungal Treatment

• Itraconazole 200 mg daily: First-line therapy for cutaneous and lymphocutaneous sporotrichosis with 90-100% success rates 1
  • Continue treatment for 2-4 weeks after all lesions have resolved (usually 3-6 months total)
  • For non-responders, dose may be increased to 200 mg twice daily
  • Capsule formulation best absorbed when taken with food
  • Oral solution best absorbed on empty stomach

Antiviral Medications

• Rimantadine 200 mg daily: Used for influenza A treatment and prophylaxis in adults and children 10 years or older 1
  • Administered as 100 mg twice daily
  • Dosage reduction to 100 mg daily recommended for:
    • Elderly patients (≥65 years)
    • Patients with severe hepatic dysfunction
    • Patients with creatinine clearance ≤10 mL/minute

Special Populations Considerations

Pediatric Patients

• For children 10 years and older weighing at least 40 kg:
  • Rimantadine: 200 mg daily (100 mg twice daily) 1
  • Amantadine: 200 mg daily (100 mg twice daily) 1

Elderly Patients (≥65 years)

• Reduced dosing often required:
  • Rimantadine: Consider 100 mg daily instead of 200 mg if side effects occur 1
  • Amantadine: Should not exceed 100 mg daily due to age-related decline in renal function 1

Clinical Pearls and Cautions

Administration Considerations

• Itraconazole capsules should be taken with food to maximize absorption 1
• Avoid agents that decrease stomach acidity when taking itraconazole capsules 1
• Monitor for side effects:
  • Itraconazole: Gastrointestinal effects (especially with solution formulation)
  • Rimantadine/Amantadine: Central nervous system effects (nervousness, anxiety, insomnia, difficulty concentrating)

Potential Pitfalls

• Inappropriate tablet manipulation: Splitting 200 mg tablets to achieve lower doses can lead to dosing inaccuracies and should be avoided when possible, especially for medications with narrow therapeutic indices 2
• Dosage adjustments: Always consider renal function, hepatic function, age, and drug interactions when prescribing 200 mg tablets 1
• Monitoring: Regular clinical assessment is essential to evaluate response and adjust therapy as needed, particularly for antifungal treatments 1

Alternative Therapies

• For patients who cannot tolerate itraconazole 200 mg daily for sporotrichosis:
  • Terbinafine 500 mg twice daily
  • SSKI (potassium iodide solution) starting at 5 drops three times daily, increasing as tolerated
  • Fluconazole 400-800 mg daily (less effective, use only if other options not tolerated) 1

By understanding the appropriate uses and dosing considerations for 200 mg tablets, clinicians can optimize therapeutic outcomes while minimizing adverse effects.