From the Guidelines
Ajovy (fremanezumab) is not typically associated with weight gain as a side effect, and clinical trials have shown no significant weight changes in patients using this medication. The medication works specifically on the calcitonin gene-related peptide (CGRP) pathway and doesn't affect hormones or metabolic processes that typically influence weight 1. Unlike some other medications used for migraines, such as certain antidepressants or anticonvulsants, Ajovy's mechanism of action does not suggest a link to weight gain.
Some key points to consider when evaluating the potential for weight gain with Ajovy include:
- The most common side effects of Ajovy are injection site reactions, such as pain, redness, or hardening of the skin at the injection site, rather than systemic effects like weight gain 1.
- If weight changes are observed, it's essential to consider other factors that might be contributing, such as other medications, lifestyle changes, or the reduction in migraine frequency allowing for increased activity or appetite.
- The management of chronic migraine, for which Ajovy is sometimes prescribed, involves addressing modifiable risk factors, including obesity, which can help prevent transformation to chronic migraine 1.
In the context of real-life clinical medicine, it is reasonable to conclude that Ajovy (fremanezumab) does not cause significant weight gain, and any observed weight changes should be evaluated in the context of other potential contributing factors, rather than attributing them to the medication itself 1.
From the Research
Ajovy (Fremanezumab) and Weight Gain
- There is no direct evidence in the provided studies that suggests Ajovy (fremanezumab) causes weight gain 2, 3, 4, 5, 6.
- The studies primarily focus on the efficacy and safety of fremanezumab for the preventive treatment of migraine, with no mention of weight gain as a potential side effect.
- Common adverse events reported in the studies include injection-site reactions, abnormalities of hepatic function, and antidrug antibody responses, but weight gain is not listed as an adverse event 3, 4.
- The long-term effects of fremanezumab on various bodily functions, including potential effects on weight, may be evaluated in ongoing trials, but current evidence does not suggest a link between fremanezumab and weight gain 5.