Rheumatoid Arthritis (RA): This is a common autoimmune disorder that often presents with migratory joint swelling, particularly affecting the hands and feet. The symmetry and pattern of joint involvement, along with morning stiffness, are key features that make RA a leading consideration.

Lyme Disease: Caused by the bacterium Borrelia burgdorferi, transmitted by tick bites. It can cause migratory arthritis, especially in the knees, and is accompanied by other symptoms like fever, headache, and a characteristic rash (erythema migrans).
Gonococcal Arthritis: A form of septic arthritis caused by Neisseria gonorrhoeae, which can present with migratory joint pain and swelling, often accompanied by skin lesions and urethritis.
Reactive Arthritis: Previously known as Reiter's syndrome, this form of arthritis occurs as a reaction to an infection elsewhere in the body, often in the gastrointestinal tract or the urethra. It can cause migratory joint pain, along with eye and urinary tract symptoms.

Septic Arthritis: Although less common, any form of septic arthritis (infection within a joint) is a medical emergency that requires prompt diagnosis and treatment to prevent joint destruction and systemic complications.
Crystal Arthropathies (Gout or Pseudogout): While these conditions typically cause acute monoarthritis, they can occasionally present with migratory symptoms, especially in the case of gout, where attacks can occur in different joints over time.
Endocarditis: Infective endocarditis, an infection of the heart valves, can cause systemic symptoms including migratory arthralgias. It's a life-threatening condition that requires early diagnosis and treatment.

Relapsing Polychondritis: A rare autoimmune disorder characterized by recurrent episodes of cartilaginous inflammation, which can affect joints among other structures like the ears, nose, and trachea.
Whipple's Disease: A rare, systemic bacterial infection (Tropheryma whipplei) that can cause migratory arthralgias along with gastrointestinal symptoms, weight loss, and neurological manifestations.
Sarcoidosis: An autoimmune disease that can affect multiple organs, including the joints, causing migratory arthralgias, although joint symptoms are less common than pulmonary or dermatological manifestations.