What is the ICD-10 (International Classification of Diseases, 10th Revision) code for Total Parenteral Nutrition (TPN)?

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Last updated: September 27, 2025View editorial policy

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ICD-10 Code for Total Parenteral Nutrition (TPN)

The ICD-10 code for Total Parenteral Nutrition (TPN) is Z99.2, which represents dependence on parenteral nutrition. This code is used to indicate that a patient requires TPN for nutritional support.

Understanding Total Parenteral Nutrition (TPN)

Total parenteral nutrition (TPN), also known as exclusive parenteral nutrition, refers to situations where:

  • The patient's complete nutritional needs (all macro and micro-nutrients) are covered by parenteral nutrition 1
  • Nutrition is not given by any route other than intravenously 1
  • It requires central venous access for administration 2

TPN is distinguished from Supplemental Parenteral Nutrition (SPN), which is used when nutrition is provided in addition to parenteral nutrition by other routes (oral or enteral) 1.

When to Use Z99.2 for TPN

The Z99.2 code should be used in the following scenarios:

  • For patients receiving complete nutritional support exclusively through intravenous administration
  • For both inpatient and outpatient (Home Parenteral Nutrition) TPN administration
  • As a secondary diagnosis to indicate the patient's dependence on this form of nutritional support

Clinical Considerations for TPN Coding

When documenting TPN for coding purposes, consider including:

  • The underlying condition necessitating TPN (e.g., short bowel syndrome, intestinal failure)
  • Duration of therapy (short-term vs. long-term)
  • Components of the TPN formulation (protein, dextrose, lipids, vitamins, minerals)
  • Central venous access device used

Common Pitfalls in TPN Coding

  • Don't confuse with enteral nutrition codes: TPN is strictly intravenous, while enteral nutrition is delivered into the gastrointestinal tract 1
  • Don't use procedure codes alone: The Z99.2 code should be used alongside the appropriate procedure codes for TPN administration
  • Don't omit the underlying condition: The primary diagnosis should reflect the reason TPN is required

Additional Coding Considerations

For more specific documentation, consider using additional codes to indicate:

  • The underlying condition requiring TPN (e.g., K91.2 for postsurgical malabsorption)
  • Complications related to TPN (if present)
  • The central venous access device in place

Remember that accurate coding is essential for proper reimbursement and for tracking the utilization of TPN in clinical settings.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Parenteral Nutrition Guidelines

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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