From the FDA Drug Label
KENALOG-40 40 mg per mL
To determine the new concentration of Kenolog (Triamcinolone) after diluting 40 mg/1ml with 5 mls, we need to calculate the total amount of triamcinolone and the total volume of the solution after dilution.
- The initial amount of triamcinolone is 40 mg.
- The initial volume is 1 ml.
- The dilution volume is 5 mls.
- The total volume after dilution is 1 ml + 5 ml = 6 ml.
- The total amount of triamcinolone remains 40 mg.
- The new concentration is 40 mg / 6 ml = 6.67 mg/ml 1
From the Research
The new concentration of Kenolog after dilution is 6.67 mg/ml. To calculate this, I started with the original concentration of 40 mg/1ml. When 5 ml of diluent is added to the original 1 ml of medication, the total volume becomes 6 ml. The amount of medication remains the same at 40 mg, but it is now distributed in 6 ml of solution. Dividing 40 mg by 6 ml gives us 6.67 mg/ml as the new concentration.
This dilution process is commonly used to adjust medication concentration for specific administration requirements. When performing such dilutions in practice, it's essential to use appropriate sterile technique and ensure thorough mixing to achieve a uniform concentration throughout the solution, as highlighted in studies on the standardization of methods for dilution of intravenous medications 2. Although the provided studies do not directly address the calculation of concentration after dilution, they emphasize the importance of proper handling and administration of medications like triamcinolone acetonide (Kenalog) to ensure safety and efficacy 3, 4, 5, 6.
Key points to consider in the dilution process include:
- Starting concentration of the medication
- Volume of the diluent added
- Final volume of the solution after dilution
- Ensuring sterile technique to prevent contamination
- Thorough mixing to achieve uniform concentration
By following these principles and calculations, healthcare professionals can accurately determine the new concentration of medications after dilution, which is critical for safe and effective patient care.